The Influence of Kisspeptin1 on Polycystic Ovarian Syndrome in Iraqi Women

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a serious gynecological condition that affects 3-10%
of women of reproductive age. The defective ovulation and menstrual disorders seen in PCOS is in
conjunction with abdominal obesity. Kisspeptins are peptides produced by the KISS1 gene that regulate
the hypothalamic-pituitary-gonadal (HPG) axis. The aim of this study was to analyze the effect of
Kisspeptin on PCOS features and obesity.
Materials and Methods: a case control study enrolled 105 participants of which 70 women have PCOS
subdivide according to their BMI to 16 obese, 19 overweight, and 35 with normal weight. The remaining
35 represent the control group who were apparently healthy women. Patients with PCOS were selected
from the Infertility Department/ Gynecology and Obstetrics Teaching Hospital in Karbala and from out
clinic patients. Measurement of serum humane Kisspeptin1 was performed using ELISA technique as well
the hormonal profile.
Results: Kisspeptin1showed significant difference among PCOS for obese, overweight and normal weight
patients against control group, (396.320 ±137.266), (419.167 ±149.660), (370.853 ±86.257) and (23.601
±52.250) respectively. The levels of LH were significantly higher (P< 0.05) among PCOS women more than
control group. There is no significant difference (P> 0.05) in Kisspeptin1 levels between three age groups.
Conclusion: Our study suggests a higher concentration of serum kisspeptin1 appeared in PCOS groups as
compared with control group as well, a substantial difference in its levels among different BMI of the study
groups. Further experimental and clinical studies are needed to ascertain the role of kisspeptin in PCOS.