The Influence of Kisspeptin1 on Polycystic Ovarian Syndrome in Iraqi Women

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a serious gynecological condition that affects 3-10% of women of reproductive age. The defective ovulation and menstrual disorders seen in PCOS is in conjunction with abdominal obesity. Kisspeptins are peptides produced by the KISS1 gene that regulate the hypothalamic-pituitary-gonadal (HPG) axis. The aim of this study was to analyze the effect of Kisspeptin on PCOS features and obesity. Materials and Methods: a case control study enrolled 105 participants of which 70 women have PCOS subdivide according to their BMI to 16 obese, 19 overweight, and 35 with normal weight. The remaining 35 represent the control group who were apparently healthy women. Patients with PCOS were selected from the Infertility Department/ Gynecology and Obstetrics Teaching Hospital in Karbala and from out clinic patients. Measurement of serum humane Kisspeptin1 was performed using ELISA technique as well the hormonal profile. Results: Kisspeptin1showed significant difference among PCOS for obese, overweight and normal weight patients against control group, (396.320 ±137.266), (419.167 ±149.660), (370.853 ±86.257) and (23.601 ±52.250) respectively. The levels of LH were significantly higher (P< 0.05) among PCOS women more than control group. There is no significant difference (P> 0.05) in Kisspeptin1 levels between three age groups. Conclusion: Our study suggests a higher concentration of serum kisspeptin1 appeared in PCOS groups as compared with control group as well, a substantial difference in its levels among different BMI of the study groups. Further experimental and clinical studies are needed to ascertain the role of kisspeptin in PCOS.