Effect Of Ribavirin on The Testicles of Adult Rabbit Males and Investigation of The Protective Role of Garlic Plant Extract Allium Sativum (Light Microscopic Study)

Abstract

Thaim of trial this stady to detect the negative effects of Ribavirin on the testicles and to identify the protective role of garlic plant extract, as in this trial used 12 adult male rabbits aged (7-9) months, the animals were randomly distributed to four groups (3 rabbits) in each group, the first group control dosed only distilled water for (30 ) days, and the second group treatment with ribavirin with , the third group treatment with garlic extract orally dosed with aqueous extract of garlic plant at a dose of (50) mg/kg for body weight per day and for (30) days Fourths group treatment with Ribavirin and garlic extract orally dosed with aqueous extract of garlic plant at a dose of (50) mg/kg for body weight per day with Ribavirin (20) mg/kg by the dosing tube and for (30) days, and then the animals were sacrificed, the results of histological examination of the castrates of male rabbits treated with Ribavirin at a concentration of (20) mg/ kg for mature spermatozoa form within the lumen .The study showed a clear improvement and the return of standards to their normal value and improved deterioration in the histological examinations of the castrated male rabbits after treatment Garlic plant extract with Ribavirin and reduce the damage and toxic effects of Ribavirin . The study of the parameters of the sperms showed the appearance of abnormalities in the shapes of the sperms treated with ribavirin compared to the control group, while the group treated with garlic extract at a dose (50) mg/kg of showed the normal shape of the sperms. Sperm shapes improved and returned to the normal level in groups of rabbits treated with garlic extract at a dose of (50) mg/kg of body weight and with ribavirin at a dose (20) mg/kg compared to the ribavirin group.