Effect Of Ribavirin in Causing Phenotypic Abnormalities and Histological Lesions in Albino Rat Fetuses and The Protective Role of Ginger Root Aqueous Extract

Abstract

The aim of this study recognition phenotypic abnormalities and histological changes in fetuses caused by Ribavirin and to detect the protective role of ginger root aqueous extract. The treatment with RBV at dose 16 mg/kg and for the period from 5 to 10 days of pregnant showed anomalies represented by the non-equal distribution of embryos on the two horns of the uterus and a small number of fetuses, and skeletal system abnormalities compared with the control group. As for the group treated with the aqueous ginger root extract at dose 200 mg/kg and for the same period , a distorted effect was observed on the fetuses, as the treatment with the extract showed a small number of fetuses and their non-equal distribution on the two horns of the uterus, as well as a small dorsum in the size of the fetus and appeared congestion in the abdominal area with torsion of the tail end compared to the control group, and it was possible to notice the irregularity of the hind limbs and dorsum Small size, mutated, deformed, incomplete and unclear rat fetus compared to the control group, and no fetus was obtained from the group treated with the drug and the extract despite repeating the experiment as a result of miscarriages that occurred during pregnancy. In the histological study of the liver of fetuses at the age of 19 days of gestation, the group treated with ribavirin showed degeneration of hepatocytes, increased numbers of macrophages, while the histological study of kidneys showed necrosis of the endothelium of the renal tubules and degeneration of renal tubule cells, while the group treated with ginger did not show any differences with the control group.