Biochemical and Immunohistochemical Findings Associated with Chronic Lead Acetate Toxicity in Female Rats

    Ali H. Ali ,Khalil H. Aljeboori

    Abstract

    In a study was designed to identify the biochemical and histochemical effect of lead acetate in female rats. Two group of female rats were taken and first group were given orally lead acetate with dose of 75 mg / kg Bw dissolved in distilled water, 2nd group as a control given phosphate buffer saline and for 90 days. The results revealed an increase in the level of liver enzymes (ALT, AST, AlP, total bilirubin and decrease protein level comparable to the control group. Immunohistochemical findings revealed few increases in CD8 markers (brown dots) on T cell wall comparable to absence or rare CD8 markers in control group T cell wall. Conclusion: Lead acetate induce elevation of the biochemical and immunohistochemical marker in female

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