This study was conducted to determine the effect of Metarhizium anisopliae (Metchnikoff) Sorokin spores and the solution of biologically fluorinated silver nanoparticles on the roles of Rhyzopertha dominica. Study of the effect of these substances on the mortality rate of the second larval phase and the complete development of the micro-grain inhibitor. The results showed: The effect of the mushroom M. Anisopliae, giving the concentration of 710 × 4 the highest death rates of the second larval age. The above-mentioned combinations gave varying killing rates at 7 days of treatment, at 76.7% of the mushroom M. Anisopliae at 710x4 spore/ml. On the other hand, the highest mortality rates were 100% for second-age larvae to concentrate 50000 ppm of silver nanoparticles while 0% were for control treatment. The highest death rate at 7 days of treatment was 70% at 710x4 spore/ml when treated with Metarhizium anisopliae. The highest death rates were recorded at 7 days of silver particle nanoparticle solution, 90% at 5,500 ppm concentration.