The purpose of this study was to analyze the effect of the application of the CLDW worksheet on science generic skills and learning outcomes. This quasi-experimental study used a nonrandomized control group pretest-posttest design and involved all tenth graders from a secondary school in Banjarmasin, Indonesia. The sample consisted of 113 students who were divided into 2 different classes. The experimental class was taught using CLDW, while the control class was taught by biology teachers using conventional worksheets. A rubric was used to assess students' answers and the results were analyzed using Mancova. Findings showthe use of CLDW significantly affects the dependent variable, namely learning outcomes and students' generic science skills after controlling for the initial abilities of students. Based on the results of the wilks lambda which has a df of 107,000 with a sig value of 0.00 (<0.005). Based on the results of the study, it can be concluded that CLDW can close the gap of generic science skills in character abilities between students in urban and suburban areas.